A recent study was published suggesting a link between the Depo-Provera shot and the development of meningiomas. A meningioma is a tumor that grows from the meninges in the brain or spinal cord. They are the most common tumor of the brain and are most commonly benign. The study was conducted as a national case-control study using the French National Health Data System. The study analyzed several different forms of progestogens: progesterone, hydroxyprogesterone, dydrogesterone, medrogestone, medroxyprogesterone acetate, promegestone, dienogest and intrauterine levonorgestrel. The study found that prolonged use of medrogestone, medroxyprogesterone acetate and promegestone were found to increase the risk of intracranial meningioma. Of note, medroxyprogesterone acetate is the main progestin in the Depo-Provera shot. The study also noted that there was no increased risk with intrauterine levonorgestrel, the form of progestin in intrauterine devices. This study sparked concern that the Depo-Provera shot may be a danger to those using it, causing speculation regarding further use of this contraceptive.